Wall St ends lower as economic data fails to ease rate hike angst



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* Meta falls as COO announces departure

* Salesforce rises after lifting profit outlook

* U.S. 10-year Treasury yield spikes to two-week high

* Indexes down: Dow 0.54%, S&P 0.75%, Nasdaq 0.72%

By Sinéad Carew, Devik Jain and Anisha Sircar

June 1 (Reuters) - Wall Street's three major indexes closed lower on Wednesday as investors bet that the latest economic data would do nothing to push the Federal Reserve off track from its aggressive interest rate hiking cycle aimed at taming run-away inflation.

Data showed that while U.S. job openings fell in April, they remained at high levels, suggesting continued wage increases contributing to uncomfortably high inflation as companies scramble for workers.

Also U.S. manufacturing activity picked up pace faster than expected in May as demand for goods remained strong, easing concerns about an imminent recession.

Along with the data, investors were monitoring public comments from several Fed officials on Wednesday. And a Fed report showed the economy in most U.S. regions expanding at a modest or moderate pace from April through late May with signs the Fed's efforts to cool demand were being felt.

But strategists said they expect the market to trade roughly sideways until inflation slows to the extent that investors could realistically bet on a pause in rate hikes.

"Unless and until we get the sustained move lower in inflation, we can't put that notion of a pause on the table," said Mona Mahajan, senior investment strategist at Edward Jones, who will closely monitor the May jobs report due out Friday and inflation readings due next week.

Investors have been watching economic data closely for clues as to what it might mean for interest rates.

"There wasn't any information to be found in today's releases that's likely to lead the Federal Reserve to become any less aggressive or to tone down its hawkishness in its rate hike campaign," said Mark Luschini, chief investment strategist, Janney Montgomery Scott.

Also on Wednesday, San Francisco Fed President Mary Daly said she sees half-point interest rate hikes in the next couple of meetings as the central bank battles high inflation, lifting rates to 2.5% as quickly as possible. This was in line with comments from Fed Governor Christopher Waller on Monday.

Jamie Dimon, chief executive of JPMorgan Chase & Co JPM.N , described the challenges facing the U.S. economy akin to an "hurricane" down the road and urged the Fed to take forceful measures to avoid tipping the world's biggest economy into a recession.

The Dow Jones Industrial Average .DJI fell 176.89 points, or 0.54%, to 32,813.23, the S&P 500 .SPX lost 30.92 points, or 0.75%, to 4,101.23 and the Nasdaq Composite .IXIC dropped 86.93 points, or 0.72%, to 11,994.46.

Among the S&P's 11 major industry sectors energy .SPNY was the sole gainer, finishing up 1.8% as oil prices rose.

The biggest laggards were financials .SPSY , down 1.7%, and healthcare .SPXHC , which was the biggest drag on the S&P 500, finishing down 1.4%. The consumer staples .SPLRCS sector lost 1.3% while materials .SPLRCM and real estate .SPLRCR also closed down more than 1%.

Uncertainty about Fed policy, the war in Ukraine and prolonged supply chain problems stemming from COVID-19 lockdowns in China have hammered stocks, with the benchmark S&P 500 index .SPX falling almost 14% year-to-date.

Stocks will be unlikely to break out on the upside before the market has more clarity on inflation and the consumer's ability to keep absorbing higher prices as well as Fed actions, said Luschini at Janney Montgomery Scott.

"There's nothing imminent, that seems likely to catalyze shedding all the worries that have driven the market down to the levels that we're at right now," he said.

The benchmark U.S. 10-year Treasury yield US10YT=RR had climbed to 2.92%, its highest in two weeks.

Late in the session, Meta Platforms FB.O tumbled and was the second-biggest drag on the S&P after Chief Operating Officer Sheryl Sandberg said in a Facebook post that she would leave the company after 14 years. It closed down 2.6%.

Salesforce CRM.N finished up 9.9% after the enterprise software firm raised its full-year adjusted profit outlook and said it did not see any material impact from the uncertain broader economic environment.

Victoria's Secret VSCO.N climbed 8.9% after the lingerie retailer beat first-quarter profit estimates as costs fell.

Declining issues outnumbered advancing ones on the NYSE by a 1.64-to-1 ratio; on Nasdaq, a 1.90-to-1 ratio favored decliners.

The S&P 500 posted one new 52-week highs and 29 new lows; the Nasdaq Composite recorded 29 new highs and 124 new lows.

On U.S. exchanges, 11.45 billion shares changed hands compared with the 13.25 billion average for the last 20 sessions.
Reporting by Sinéad Carew in New York, Devik Jain and Anisha Sircar in Bengaluru; Editing by Marguerita Choy

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