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By Shashwat Chauhan and Shristi Achar A

Jan 24 (Reuters) -UK's blue-chip index closed in the red onTuesday, with healthcare and commodity stocks leading losses after data showed British private-sector economic activity fell at its fastest rate in two years in January.

The FTSE 100 .FTSE closed the session 0.4% lower, with drugmaker AstraZeneca AZN.L and miner Glencore GLEN.L being the top drags.

The S&P Global/CIPS flash composite Purchasing Managers' Index (PMI) dropped to 47.8 in January from 49.0 in December, at the bottom end of economist forecasts, as businesses blamed higher Bank of England interest rates, strikes and weak consumer demand for the slowdown.

"The PMI wasn't particularly robust. It is a reminder that 2023, from a macroeconomic perspective, is likely to be a challenging year," said Richard Flax, chief investment officer at Moneyfarm.

The healthcare .FTNMX201030 and mining .FTNMX551020 sectors fell 2.4% and 0.7% respectively.

Separately, data showed Britain's government borrowed more last month than in any December since monthly records began 30 years ago, reflecting the huge cost of energy support and soaring debt interest linked to rising inflation.

"A difficult morning for the UK data-wise, as the higher-than-expected borrowing figures highlight the tight fiscal constraints the government is working under," said Stuart Cole, head macro economist at Equiti Capital.

Market participants are pricing in a 69.5% chance of a 50-basis-point hike by the Bank of England next week. 0#BOEWATCH

Interest rate hikes are expected to continue with the U.S. Federal Reserve and the European Central Bank coming out with their monetary policy decisions next week.

Senior SNR.L surged 7.5% after the aerospace company said its adjusted profit for 2022 is expected to exceed expectations, pushing the FTSE 250 midcaps .FTMC to close up 0.3%.

Associated British Foods ABF.L fell 2.0% after the group cautioned economic headwinds may dent consumer spending in 2023.

Aircraft engine maker Rolls-Royce RR.L gained 3.0% to the top of FTSE 100after Exane BNP Paribasupgraded the stock to "neutral" from "underperform" on the company having a balanced risk-reward ratio.

Reporting by Shashwat Chauhan and Shristi Achar A in Bengaluru; Editing by Rashmi Aich, Krishna Chandra Eluri and Mark Heinrich

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